Description

Pdgfr Tyrosine Kinase Inhibitor Iii is a potent and selective small molecule inhibitor targeting the platelet-derived growth factor receptor (PDGFR) family, a key signaling pathway in cellular proliferation and angiogenesis. This compound is essential for researchers and developers in the life sciences sector, providing a critical tool for investigating oncogenic mechanisms and validating therapeutic targets. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, fibrosis, and cardiovascular disease research.

Application

• Biochemical Research: Used as a selective inhibitor to study PDGFR-mediated signal transduction pathways in cell-based assays.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel anti-cancer and anti-fibrotic therapeutics.
• Target Validation: Employed in preclinical studies to validate the PDGFR as a therapeutic target in various disease models.
• Academic Research: A key reagent for investigating the role of tyrosine kinases in cellular processes like proliferation, migration, and differentiation.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify new PDGFR inhibitors.

Basic Information

Product Name	Pdgfr Tyrosine Kinase Inhibitor Iii
CAS No.	205254-94-0
Molecular Formula	C₂₁H₂₀N₄O₃
Molecular Weight	376.41 g/mol
Synonyms	PDGFR Inhibitor III; Tyrphostin AG 1296; AG 1296; AG-1296; 6,7-Dimethoxy-2-phenylquinoxaline; 6,7-Dimethoxy-2-phenylquinoxaline; (E)-α-Cyano-3,4-dihydroxy-N-benzylcinnamamide (common mis-association, included for clarity); Quinoxaline tyrosine kinase inhibitor
EINECS	Contact for details

Quality Control

Our Pdgfr Tyrosine Kinase Inhibitor Iii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.