Description

2-Fluoro-5-Iodo-3-Picoline is a halogenated pyridine derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable building block for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. Its unique substitution pattern makes it a critical intermediate for medicinal chemists and R&D professionals developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl systems.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological systems and mechanisms.

Basic Information

Product Name	2-Fluoro-5-Iodo-3-Picoline
CAS No.	205245-17-6
Molecular Formula	C6H5FIN
Molecular Weight	237.02 g/mol
Synonyms	5-Iodo-2-fluoro-3-methylpyridine; 3-Methyl-5-iodo-2-fluoropyridine; 2-Fluoro-5-iodo-3-methylpyridine; 2-Fluoro-3-methyl-5-iodopyridine; 2-Fluoro-5-iodo-3-picoline; 205245-17-6; 3-Picoline, 2-fluoro-5-iodo-
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Iodo-3-Picoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.