Description

2-(Difluoromethoxy)Pyridin-4-Ol is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its unique difluoromethoxy-pyridinol structure makes it a valuable intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs of biological molecules for metabolic pathway studies and imaging.

Basic Information

Product Name	2-(Difluoromethoxy)Pyridin-4-Ol
CAS No.	205043-09-0
Molecular Formula	C6H5F2NO2
Molecular Weight	161.11 g/mol
Synonyms	4-Hydroxy-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-4-hydroxypyridine; 2-(Difluoromethoxy)-4-pyridinol; 4-Pyridinol, 2-(difluoromethoxy)-; 205043-09-0; Difluoromethoxy pyridinol intermediate
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Pyridin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical and agrochemical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.