Description

Indibulin is a synthetic small molecule tubulin polymerization inhibitor with significant research and therapeutic interest. Its primary value lies in its potent anti-mitotic activity, which makes it a compelling candidate for oncology research and drug development. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and academic researchers focused on developing novel cancer therapeutics, particularly for solid tumors.

Application

• Oncology Research & Drug Development: A key investigational agent in preclinical and clinical studies for various cancers, including breast cancer and glioblastoma.
• Mechanistic Studies: Used as a biochemical tool to study tubulin dynamics, cell cycle arrest, and apoptosis signaling pathways.
• Pharmaceutical Intermediates: Serves as a critical active pharmaceutical ingredient (API) or intermediate in the synthesis of targeted cancer therapies.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside other chemotherapeutic agents or radiation.
• Academic & Institutional Research: Employed in university and research institute laboratories for fundamental cancer biology and pharmacology studies.

Basic Information

Product Name	Indibulin
CAS No.	204205-90-3
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-(1H-indol-3-yl)-2-oxoacetamide; ZIO-301; ZIO 301; BNC 105; BNC-105; BNC105; Indibulin (ZIO-301); (Z)-2-(1H-Indol-3-yl)-2-oxo-N-[4-(1H-benzimidazol-2-yl)phenyl]acetamide
EINECS	Contact for details

Quality Control

Our Indibulin is manufactured under strict quality management systems to ensure the highest standards of purity and consistency required for research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing under inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	Off-white to yellow solid powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.