Description

Su 5416 is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase. This compound is a critical research tool for studying angiogenesis, tumor growth, and related signaling pathways in preclinical models. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, cardiovascular disease, and anti-angiogenic therapeutic development.

Application

• Angiogenesis Research: A key pharmacological agent for inhibiting VEGF-induced signaling and studying blood vessel formation in cellular and animal models.
• Oncology Studies: Used extensively in cancer research to investigate the role of VEGFR-2 in tumor growth, metastasis, and as a potential target for anti-cancer drugs.
• Biochemical Assay Standard: Serves as a reference standard in high-throughput screening (HTS) and enzyme inhibition assays for kinase profiling.
• Pharmaceutical Development: Employed as a lead compound or tool molecule in the discovery and development stages of novel tyrosine kinase inhibitors.
• Academic & Contract Research: Utilized in universities and CROs for mechanistic studies in cell biology, pathology, and molecular pharmacology.

Basic Information

Product Name	Su 5416
CAS No.	204005-46-9
Molecular Formula	C21H16N4O3
Molecular Weight	372.38 g/mol
Synonyms	Semaxanib; SU5416; 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; VEGF Receptor 2 Kinase Inhibitor II; Z-3-[(2,4-Dimethyl-5H-pyrrol-5-yl)methylene]-1,3-dihydro-2H-indol-2-one; VEGFR2 Inhibitor SU5416; NSC 696819
EINECS	Contact for details

Quality Control

Our Su 5416 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.