Description

Karenitecin is a synthetic, lipophilic camptothecin analog and a potent topoisomerase I inhibitor. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and manufacturers focused on oncology drug discovery and formulation. The product is supplied as a high-purity chemical entity, essential for ensuring the efficacy and safety of final drug products.

Application

• Oncology Drug Development: Serves as a key active pharmaceutical ingredient (API) in the formulation of injectable and oral anticancer medications.
• Pharmaceutical Research: Used as a reference standard and biochemical tool in cancer biology studies to investigate topoisomerase I inhibition mechanisms.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and toxicity profiles.
• Drug Delivery System Development: A candidate for encapsulation in liposomal, nanoparticle, or other advanced delivery platforms to enhance solubility and target specificity.
• Combinatorial Therapy Research: Investigated in combination with other chemotherapeutic agents or radiation to assess synergistic effects.
• Analytical Method Development: Used to develop and validate HPLC, LC-MS, and other analytical methods for quality control and bioanalysis.

Basic Information

Product Name	Karenitecin
CAS No.	203923-89-1
Molecular Formula	C26H25FN2O5
Molecular Weight	464.49 g/mol
Synonyms	BNP1350; 7-[(4-Methylpiperazino)methyl]-10,11-(ethylenedioxy)-20(S)-camptothecin; 10,11-Methylenedioxy-20(S)-camptothecin 7-(4-methylpiperazinomethyl) derivative; Karenitecin (BNP1350); (S)-10,11-Methylenedioxy-20-camptothecin 7-(4-methyl-1-piperazinyl)methyl; BNP-1350; UNII-1B3P6VH55I
EINECS	Contact for details

Quality Control

Our Karenitecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.