Description

Monomethyl Dolastatin 10 is a potent synthetic derivative of the natural marine cytotoxin Dolastatin 10, designed for advanced research applications. This compound is of significant interest for its role as a key intermediate and payload in the development of antibody-drug conjugates (ADCs) and other targeted cancer therapeutics. Researchers and pharmaceutical developers in the fields of oncology, medicinal chemistry, and bioconjugation require this high-purity building block to investigate novel treatment modalities and optimize drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent cytotoxic warhead for conjugation to monoclonal antibodies targeting specific cancer cells.
• Oncology Research: Used in in vitro and in vivo studies to evaluate antitumor efficacy, mechanism of action, and pharmacokinetics.
• Medicinal Chemistry & Drug Discovery: A critical intermediate for synthesizing and screening novel tubulin polymerization inhibitors and cytotoxic analogs.
• Bioconjugation & Linker Chemistry: Employed in developing and optimizing cleavable and non-cleavable linker systems for targeted therapies.
• Preclinical Development: Supports toxicity studies, formulation development, and stability testing for next-generation chemotherapeutic agents.

Basic Information

Product Name	Monomethyl Dolastatin 10
CAS No.	203849-91-6
Molecular Formula	C37H58N4O6S
Molecular Weight	686.95 g/mol
Synonyms	MMAD; Monomethylauristatin D; N-[(3R,4S,5S)-1-[(2S)-2-[[(1S,2R)-1-Hydroxy-1-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropyl]-4-methyl-1-oxo-1,5-diphenylpentan-3-yl]-N-methyl-L-valinamide; (3R,4S,5S)-4-[(2S)-2-[(1S,2R)-1-Hydroxy-1-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropyl]-3-methyl-1-oxo-1,5-diphenylpentan-4-yl] N-methyl-L-valinate; Dolastatin 10 Monomethyl Derivative; Auristatin MMAE Analog
EINECS	Contact for details

Quality Control

Our Monomethyl Dolastatin 10 is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for sensitive research and development work. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for advanced pharmaceutical intermediates, and custom purity grades or analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.