Description

4-Chloro-2-Fluoro-5-Iodotoluene is a halogenated toluene derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the construction of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), functional materials, and specialized chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and functional group transformations to introduce the toluidine scaffold into more complex architectures.

Basic Information

Item	Detail
Product Name	4-Chloro-2-Fluoro-5-Iodotoluene
CAS No.	202982-69-2
Molecular Formula	C7H5ClFI
Molecular Weight	269.47 g/mol
Synonyms	1-Chloro-4-fluoro-2-iodo-5-methylbenzene; 2-Fluoro-4-chloro-5-iodotoluene; 5-Iodo-2-fluoro-4-chlorotoluene; 4-Chloro-2-fluoro-5-iodo-1-methylbenzene; Toluene, 4-chloro-2-fluoro-5-iodo-; 2-Fluoro-4-chloro-α,α,5-triiodotoluene (incorrect but sometimes listed); Benzoic acid, 4-chloro-2-fluoro-5-iodo- (related acid form)
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluoro-5-Iodotoluene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity requirements for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to direct light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Total impurities < 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.