Description

4-Bromo-2-Fluoro-5-Iodotoluene is a halogenated toluene derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and valuable multi-functionalized aromatic building block, enabling precise molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating complex target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring specific halogen substitution patterns for bioactivity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the bromo, fluoro, and iodo groups act as critical functional handles.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating halogenated aromatic cores in advanced electronic and photonic materials.
• Cross-Coupling Reactions: An excellent substrate for various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the presence of reactive bromo and iodo groups.
• Chemical Biology & Proteomics: Can be used to synthesize probes and tags for labeling and studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research and scale-up projects.

Basic Information

Product Name	4-Bromo-2-Fluoro-5-Iodotoluene
CAS No.	202865-74-5
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	1-Bromo-4-fluoro-2-iodo-5-methylbenzene; 2-Fluoro-4-bromo-5-iodotoluene; 5-Iodo-4-bromo-2-fluorotoluene; Toluene, 4-bromo-2-fluoro-5-iodo-; 4-Bromo-2-fluoro-5-iodo-1-methylbenzene; BFIT (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Fluoro-5-Iodotoluene is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure high purity and batch-to-batch consistency, critical for reproducible research and process development. A detailed Certificate of Analysis (COA) including HPLC purity, identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed when not in use to prevent contamination and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.