Description

Jak3 Inhibitor I is a potent and selective small molecule inhibitor of the Janus kinase 3 (JAK3) enzyme. This compound is a critical research tool for investigating JAK-STAT signaling pathways, which are central to immune cell function and cytokine signaling. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, autoimmune diseases, and oncology research.

Application

• Biochemical Research: A key reagent for studying the role of JAK3 in T-cell and NK-cell signaling and development.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for JAK3-targeted therapies.
• Immunology Studies: Facilitates research into autoimmune and inflammatory conditions such as rheumatoid arthritis, psoriasis, and transplant rejection by modulating JAK3 activity.
• Oncology Research: Investigated for its potential in hematological cancers where JAK3 signaling pathways are dysregulated.
• Cellular Pathway Analysis: Employed in vitro to dissect the specific contributions of JAK3 within the broader JAK-STAT signaling network.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in cell biology and signal transduction.

Basic Information

Product Name	Jak3 Inhibitor I
CAS No.	202475-60-3
Molecular Formula	C₂₂H₂₁N₅O₂
Molecular Weight	387.44 g/mol
Synonyms	4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline; WHI-P154; JANEX-1; JAK3 Inhibitor WHI-P154; 6,7-Dimethoxy-4-[(4-hydroxyphenyl)amino]quinazoline; 4-[(4-Hydroxyphenyl)amino]-6,7-dimethoxyquinazoline; NSC 74859; EGFR Inhibitor (WHI-P154)
EINECS	Contact for details

Quality Control

Our Jak3 Inhibitor I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.