Description

L-Leucine (U-13C6) is a stable isotope-labeled form of the essential amino acid L-Leucine, where all six carbon atoms are uniformly replaced with the 13C isotope. This high-purity labeled compound is critical for advanced research requiring precise metabolic tracing and quantification in complex biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutritional science sectors for applications in mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Metabolic Pathway Analysis: Used as an internal standard in mass spectrometry (MS) and gas chromatography-mass spectrometry (GC-MS) for accurate quantification of L-Leucine and related metabolites in biological samples.
• Proteomics & Biomarker Research: Essential for stable isotope labeling by amino acids in cell culture (SILAC) experiments to study protein expression, turnover, and post-translational modifications.
• Pharmacokinetic & Drug Metabolism Studies: Employed in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Clinical Diagnostics: Serves as a key component in the development of isotopic dilution assays for the diagnosis of metabolic disorders such as maple syrup urine disease (MSUD).
• Nutritional Research: Applied in studies examining protein synthesis, muscle metabolism, and amino acid requirements in various physiological states.
• NMR Spectroscopy: Provides a non-radioactive, stable tracer for structural and dynamic studies of proteins and other biomolecules using nuclear magnetic resonance.

Basic Information

Product Name	L-Leucine (U-13C6)
CAS No.	202406-52-8
Molecular Formula	13C6H13NO2
Molecular Weight	137.12 (based on 13C)
Synonyms	(2S)-2-Amino-4-methyl(1,2,3,4,5,6-13C6)pentanoic acid; L-(U-13C6)Leucine; Uniformly Labeled 13C6-L-Leucine; Leucine-13C6; (S)-2-Amino-4-methylpentanoic-13C6 acid; Isotopic L-Leucine; 13C6-Leu
EINECS	Contact for details

Quality Control

Our L-Leucine (U-13C6) is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), chiral purity, and other critical parameters. We adhere to relevant industry standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chiral Purity ([α]D)	≥99.0% L-Isomer
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.