Description

Choline Chloride (1,2-13C2, 99%) is a stable isotope-labeled analog of the essential nutrient choline, where two carbon atoms at the 1 and 2 positions are enriched with the 13C isotope to 99% purity. This high isotopic enrichment is critical for providing an internal standard or tracer in advanced analytical and metabolic research, ensuring precise quantification and tracking. It is primarily required by research scientists and pharmaceutical developers in the fields of metabolomics, nutritional studies, and drug metabolism research where accurate mass spectrometry data is paramount.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-mass spectrometry for the accurate measurement of choline and its metabolites in complex biological samples.
• Metabolic Pathway Tracing: Employed in 13C isotopic tracer studies to elucidate choline's metabolic flux, absorption, and conversion to betaine or phospholipids in vivo.
• Pharmaceutical R&D: Serves as a labeled precursor in the development and pharmacokinetic analysis of new drugs targeting cholinergic systems or lipid metabolism.
• Clinical Research: Facilitates precise studies on choline deficiency, fatty liver disease, and neurological disorders by enabling differentiation between endogenous and supplemented choline.
• Nutrient Fortification Studies: Used in nutritional science to track the bioavailability and utilization of choline from fortified foods or supplements.
• Biochemical Assay Development: Integral for creating highly specific and sensitive diagnostic assays for choline-related biomarkers.

Basic Information

Product Name	Choline Chloride (1,2-13C2, 99%)
CAS No.	202190-49-6
Molecular Formula	C513C2H14ClNO
Molecular Weight	141.59 g/mol (for 13C2 labeled form)
Synonyms	(2-Hydroxyethyl)trimethylammonium chloride (1,2-13C2); Biocolina; Hepacholine; 2-Hydroxy-N,N,N-trimethylethanaminium chloride (13C2); (β-Hydroxyethyl)trimethylammonium chloride-13C2; Choline chloride-1,2-13C2; Lipotril; 13C-Labeled Choline Chloride
EINECS	Contact for details

Quality Control

Every batch of our Choline Chloride (1,2-13C2, 99%) is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods. Our quality commitment aligns with the rigorous standards expected in analytical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of water vapor. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99% at 1,2 positions
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Solubility	Freely soluble in water, soluble in alcohol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.