Description

Ly 341495 is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist, widely recognized in neuroscience research. This high-purity compound is essential for investigating glutamatergic signaling pathways and their implications in neurological and psychiatric disorders. It is a critical tool for pharmaceutical R&D, academic institutions, and contract research organizations focused on CNS drug discovery and neuropharmacology.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of group II mGluRs in synaptic transmission, plasticity, and neuronal excitability.
• Psychiatric Disorder Models: Used in preclinical research to investigate potential therapeutic targets for conditions such as anxiety, depression, and schizophrenia.
• Neurological Disease Studies: Applied in models of Parkinson's disease, epilepsy, and chronic pain to understand glutamate receptor involvement.
• Drug Discovery & Development: Serves as a reference standard and active compound in high-throughput screening and lead optimization for CNS-targeted therapeutics.
• Academic & Institutional Research: Supports fundamental research in university and government laboratories exploring glutamate receptor biology.
• Biochemical Assay Development: Utilized as a control compound in developing and validating receptor binding and functional cell-based assays.

Basic Information

Product Name	Ly 341495
CAS No.	201943-63-7
Molecular Formula	C₁₈H₁₆F₂N₂O₃
Molecular Weight	346.33 g/mol
Synonyms	(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid; (2S)-2-Amino-2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)propanoic acid; LY341495; LY 341495; 2S-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(9H-xanthen-9-yl)propanoic acid; mGluR2/3 antagonist LY341495
EINECS	Contact for details

Quality Control

Our Ly 341495 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.