Description

2-Chloro-5-Methoxybenzene-1-Sulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, enabling the efficient introduction of both a sulfonamide linkage and a substituted aromatic system into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with tailored activity profiles.
• Functional Material Research: Used in the creation of specialty polymers, dyes, and liquid crystals where the sulfonyl group imparts specific chemical or physical properties.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Chloro-5-Methoxybenzene-1-Sulfonyl Chloride
CAS No.	201935-41-3
Molecular Formula	C7H6Cl2O3S
Molecular Weight	241.09 g/mol
Synonyms	2-Chloro-5-methoxybenzenesulfonyl chloride; 1-Chloro-2-methoxy-4-(chlorosulfonyl)benzene; 4-Chloro-3-methoxybenzenesulfonyl chloride; 2-Methoxy-5-chlorobenzenesulfonyl chloride; 5-Chloro-2-methoxybenzene-1-sulfonyl chloride; 3-Methoxy-4-chlorobenzenesulfonyl chloride; 2-Chloro-5-methoxyphenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Methoxybenzene-1-Sulfonyl Chloride is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.