Description

5-Bromo-4-Chloro-2-Fluorotoluene is a halogenated toluene derivative that serves as a versatile and critical building block in advanced organic synthesis. Its precise substitution pattern makes it a valuable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated and halogenated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Functional Material Development: Employed in polymer chemistry and material science to create specialty monomers and polymers with tailored electronic or physical properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification of chemical space.
• Research & Development: A high-purity standard for analytical method development and as a reference compound in academic and industrial R&D laboratories.

Basic Information

Product Name	5-Bromo-4-Chloro-2-Fluorotoluene
CAS No.	201849-18-5
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Fluoro-5-bromo-4-chlorotoluene; 1-Bromo-2-chloro-5-fluoro-4-methylbenzene; 4-Chloro-5-bromo-2-fluorotoluene; Toluene, 5-bromo-4-chloro-2-fluoro-; 2-Fluoro-4-chloro-5-bromotoluene; 5-Bromo-4-chloro-2-fluoro-1-methylbenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-2-Fluorotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee batch-to-batch consistency and traceability for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.