Description

L-Leucine-13C6 is a stable isotope-labeled analog of the essential branched-chain amino acid L-Leucine, where all six carbon atoms are replaced with the 13C isotope. This compound is critical for advanced metabolic research, enabling precise tracking and quantification of amino acid flux, protein synthesis, and metabolic pathways using techniques like mass spectrometry and NMR. It is an indispensable tool for pharmaceutical R&D, clinical diagnostics, and nutritional science laboratories requiring high isotopic purity and chemical stability for accurate tracer studies.

Application

• Stable Isotope Tracer Studies: Used in metabolic flux analysis (MFA) to investigate protein metabolism, energy pathways, and amino acid utilization in cell cultures, tissues, and whole organisms.
• Quantitative Proteomics & Biomarker Discovery: Serves as an internal standard for the absolute quantification of proteins and peptides via mass spectrometry-based methods like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed to trace the metabolic fate of drug candidates, study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Research & Diagnostics: Applied in human metabolic studies to understand disorders related to leucine metabolism, such as maple syrup urine disease (MSUD), and to assess nutritional status.
• Nutritional Science Research: Utilized to study muscle protein synthesis, the impact of dietary supplements, and whole-body protein turnover in sports science and aging research.
• NMR Spectroscopy: Acts as a 13C-enriched substrate for nuclear magnetic resonance studies to elucidate molecular structures and dynamic processes in complex biological systems.

Basic Information

Product Name	L-Leucine-13C6
CAS No.	201740-84-3
Molecular Formula	13C6H13NO2
Molecular Weight	137.12 (based on 13C)
Synonyms	(2S)-2-Amino-4-methyl-13C6-pentanoic acid; L-(13C6)Leucine; (S)-2-Amino-4-methylpentanoic acid-13C6; Leucine-13C6; (S)-2-Amino-4-methylvaleric acid-13C6; (S)-Leucine-13C6; H-Leu-13C6-OH; 13C6-L-Leucine
EINECS	Contact for details

Quality Control

Our L-Leucine-13C6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity, chiral purity, and residual solvent analysis. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and weighing accuracy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 99 atom % 13C
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.