Description

(R)-3,4-Dcpg CAS NO 201730-10-1 is a high-purity chiral compound, specifically the (R)-enantiomer of 3,4-dicarboxyphenylglycine, which serves as a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist. This specificity makes it a critical research tool for neuroscience and pharmacology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on developing and studying neurological therapeutics and receptor mechanisms.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and modulation of group II metabotropic glutamate receptors (mGluR2/3) in the central nervous system.
• Drug Discovery & Development: Used as a reference standard and building block in the R&D of novel therapeutics targeting neurological disorders such as anxiety, depression, schizophrenia, and Parkinson's disease.
• Biochemical Assays: Employed in in vitro and in vivo assays to investigate receptor binding, signal transduction pathways, and synaptic plasticity.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental studies on glutamate receptor biology and neuropharmacology.
• Fine Chemical Synthesis: Serves as a chiral intermediate or precursor for the synthesis of more complex, receptor-targeted molecules.

Basic Information

Product Name	(R)-3,4-Dcpg
CAS No.	201730-10-1
Molecular Formula	C10H9NO6
Molecular Weight	239.18 g/mol
Synonyms	(R)-3,4-Dicarboxyphenylglycine; (R)-3,4-DCPG; (R)-α-Amino-3,4-dicarboxybenzenepropanoic acid; (R)-3-(3,4-Dicarboxyphenyl)alanine; (2R)-2-Amino-3-(3,4-dicarboxyphenyl)propanoic acid; (R)-mGluR2 antagonist; Group II mGluR antagonist (R)-isomer
EINECS	Contact for details

Quality Control

Our (R)-3,4-Dcpg is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, essential for reliable research outcomes. Each lot undergoes comprehensive analytical testing including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.