Description

Prostaglandin A2-D4 is a deuterium-labeled analog of Prostaglandin A2, a key member of the prostanoid family of bioactive lipids. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring precise and accurate analytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for drug metabolism studies, pharmacokinetic research, and biomarker analysis.

Application

• Quantitative Mass Spectrometry (LC-MS/MS): Serves as a critical internal standard for the accurate quantification of endogenous Prostaglandin A2 and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and analyzing the metabolic pathways and bioavailability of pharmaceutical compounds affecting the arachidonic acid cascade.
• Biomarker Research: Enables precise measurement of prostaglandin levels in clinical and preclinical studies for investigating inflammation, cancer, and cardiovascular diseases.
• Analytical Method Development: Aids in the validation and calibration of sensitive bioanalytical assays to meet regulatory standards for data integrity.
• Stable Isotope Labeling Studies: Facilitates advanced research in lipidomics and eicosanoid profiling to understand biochemical mechanisms and signaling pathways.

Basic Information

Product Name	Prostaglandin A2-D4
CAS No.	201608-18-6
Molecular Formula	C₂₀H₂₈D₄O₅
Molecular Weight	340.47 g/mol (approx.)
Synonyms	PGA2-d4; 5,6,8,11-Prostaglandin A2-d4; (5Z,13E)-(15S)-9-Oxo-11α,15-dihydroxyprosta-5,13-dien-1-oic-17,17,18,18-d4 acid; 9-Oxo-11α,15-dihydroxyprosta-5,13-dien-1-oic-17,17,18,18-d4 acid; Deuterated PGA2; [17,17,18,18-²H₄]-PGA₂
EINECS	Contact for details

Quality Control

Our Prostaglandin A2-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and deuterium incorporation is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep the product in its original packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.