Description

Cell-Permeable Caspase-3 Inhibitor I Trifluoroacetate Salt is a potent, cell-permeable peptide inhibitor designed to selectively target and inhibit caspase-3 activity. This compound is a critical research tool for investigating apoptotic pathways and for validating the role of caspase-3 in cellular models of disease. It is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and biotechnology focused on neuroprotection, oncology, and other apoptosis-related fields.

Application

• Apoptosis Research: Used as a key reagent to inhibit caspase-3 activity in cell-based assays to study programmed cell death mechanisms.
• Neuroprotective Studies: Applied in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, stroke) to assess the role of caspase-3 in neuronal cell death.
• Oncology Research: Employed to investigate the sensitivity of cancer cell lines to chemotherapeutic agents by modulating apoptotic thresholds.
• Cardioprotection Models: Utilized in research on ischemia-reperfusion injury to understand and mitigate caspase-3-mediated damage in cardiac tissue.
• Inflammatory Disease Research: Helps in elucidating the cross-talk between apoptosis and inflammation in conditions like rheumatoid arthritis and liver disease.
• Drug Discovery & Validation: Serves as a positive control and a pharmacological tool in high-throughput screening (HTS) campaigns for novel caspase-3 inhibitor discovery.
• Biochemical Assay Development: Acts as a standard inhibitor in enzymatic assays to characterize caspase-3 kinetics and inhibitor potency (IC50 determination).

Basic Information

Product Name	Cell-Permeable Caspase-3 Inhibitor I Trifluoroacetate Salt
CAS No.	201608-15-3
Molecular Formula	C24H39F3N8O7
Molecular Weight	608.61 g/mol
Synonyms	Z-DEVD-FMK; Caspase-3 Inhibitor II; Ac-Asp-Glu-Val-Asp-CHO; Ac-DEVD-CHO; N-Acetyl-Asp-Glu-Val-Asp-al; (2S)-5-[[(2S)-4-[[(2S)-1-[(2S)-2-Acetamido-3-carboxypropanoyl]pyrrolidin-2-yl]-oxomethyl]amino]-4-oxobutanoyl]amino]-2-[[(2S)-3-methyl-1-oxobutyl]amino]pentanoic acid; DEVD-CHO; Caspase 3/7 Inhibitor I
EINECS	Contact for details

Quality Control

Our Cell-Permeable Caspase-3 Inhibitor I Trifluoroacetate Salt is manufactured under strict quality systems suitable for research use. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure traceability and meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, slightly soluble in water
Biological Activity (IC50)	≤20 nM (vs. caspase-3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.