Description

Cell-Permeable Caspase-1 Inhibitor I Trifluoroacetate Salt is a potent, cell-permeable inhibitor of the interleukin-1β converting enzyme (ICE/Caspase-1), a key mediator of inflammatory responses. This compound is crucial for researchers investigating pyroptosis and the role of Caspase-1 in various disease models, including autoimmune disorders and neuroinflammation. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on inflammation and apoptosis pathways.

Application

• Biochemical Research: A critical tool for studying the mechanisms of pyroptosis, inflammasome activation, and interleukin-1β processing in cellular models.
• Pharmaceutical Development: Used in high-throughput screening and target validation for drug discovery programs targeting inflammatory diseases like rheumatoid arthritis, gout, and Alzheimer's disease.
• Immunology Studies: Enables the investigation of Caspase-1's role in innate immunity, host defense, and autoimmune conditions.
• Neuroinflammation Research: Applied in models of neurological disorders to dissect the contribution of inflammatory caspases to disease pathology.
• In Vitro Diagnostics: Serves as a reference standard and control in assay development for Caspase-1 activity.

Basic Information

Product Name	Cell-Permeable Caspase-1 Inhibitor I Trifluoroacetate Salt
CAS No.	201608-12-0
Molecular Formula	C20H27F3N4O4 • C2HF3O2
Molecular Weight	548.5 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-CHO Trifluoroacetate Salt; Ac-YVAD-CHO TFA Salt; Caspase-1 Inhibitor I, Cell-Permeable; ICE Inhibitor I; Acetyl-Tyr-Val-Ala-Asp-al TFA; Interleukin-1β Converting Enzyme Inhibitor I; Z-YVAD-FMK (related fluoromethyl ketone inhibitor); Ac-YVAD-CMK (related chloromethyl ketone inhibitor)
EINECS	Contact for details

Quality Control

Our Cell-Permeable Caspase-1 Inhibitor I Trifluoroacetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity is provided with every shipment, supporting research reproducibility and compliance with laboratory quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Biological Activity (IC50)	≤ 1 nM (Caspase-1 inhibition)
Solubility	Soluble in DMSO, ethanol, and aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.