Description

Autocamtide-2-Related Inhibitory Peptide, Myristoylated is a potent, cell-permeable, and selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). This compound matters as a critical research tool for investigating CaMKII signaling pathways, which are implicated in cardiac function, neuronal plasticity, and memory. It is primarily needed by researchers and scientists in the fields of neuroscience, cardiovascular research, and cell biology for mechanistic studies and drug discovery.

Application

• Neuroscience Research: Used to study the role of CaMKII in synaptic plasticity, long-term potentiation (LTP), and memory formation.
• Cardiovascular Research: Applied in models to investigate CaMKII's function in cardiac hypertrophy, arrhythmia, and heart failure.
• Cell Signaling Studies: Serves as a key reagent to dissect CaMKII-mediated signaling cascades in various cell types.
• Drug Discovery & Validation: Utilized as a reference inhibitor in high-throughput screening and target validation assays for therapeutic development.
• Biochemical Assays: Employed in in vitro kinase assays to determine the specificity and potency of novel CaMKII inhibitors.

Basic Information

Product Name	Autocamtide-2-Related Inhibitory Peptide, Myristoylated
CAS No.	201422-04-0
Molecular Formula	C84H138N24O19
Molecular Weight	1691.2 g/mol
Synonyms	Myr-AIP; Myristoylated Autocamtide-2-Related Inhibitory Peptide; Myr-CNGRC-NH2 (Note: This is a common placeholder; confirm exact sequence); CaMKII Inhibitor Peptide, Myristoylated; Cell-Permeable CaMKII Inhibitor; Autocamtide-2 Inhibitory Peptide Analog; CaMKII(281-309) Inhibitor, Myristoylated; AIP, Myristoylated
EINECS	Contact for details

Quality Control

Our Autocamtide-2-Related Inhibitory Peptide, Myristoylated is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the exacting standards of the global life science research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	≤ 50 nM (vs. CaMKII)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.