Description

Protein Kinase A Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated is a potent and selective synthetic peptide inhibitor of cyclic AMP-dependent protein kinase (PKA). Its cell-permeable, myristoylated design is critical for efficient intracellular delivery, enabling direct modulation of PKA activity in live-cell and in vivo research models. This inhibitor is an essential tool for researchers in molecular biology, neurobiology, and pharmacology studying cAMP/PKA signaling pathways, cellular differentiation, and metabolic regulation.

Application

• Biochemical Research: Fundamental studies of cAMP/PKA signal transduction mechanisms and kinase-substrate interactions.
• Neurobiology & Cardiology: Investigation of PKA's role in neuronal plasticity, memory formation, and cardiac contractility.
• Cancer Research: Exploration of PKA signaling in tumor cell proliferation, survival, and metastasis.
• Metabolic Studies: Analysis of PKA function in glycogen metabolism, lipolysis, and hormone regulation.
• Drug Discovery: Used as a reference compound and pharmacological tool for validating PKA-targeted therapeutics in high-throughput screening (HTS).
• Cell Culture & Functional Assays: Direct application in live-cell imaging and functional assays to acutely inhibit PKA activity.

Basic Information

Product Name	Protein Kinase A Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated
CAS No.	201422-03-9
Molecular Formula	C53H95N15O13
Molecular Weight	1134.4 g/mol
Synonyms	PKA Inhibitor 14-22 Amide, Myristoylated; PKI(14-22)-amide, Myr; Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2; Myristoylated PKI; cAMP-dependent Protein Kinase Inhibitor (14-22) amide, cell-permeable; H-Myr-GRTGRRNAI-NH2; Protein Kinase A Inhibitor Peptide (14-22); PKI
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Protein Kinase A Inhibitor 14-22 Amide is characterized by advanced analytical techniques to guarantee identity, purity, and biological activity. Certificates of Analysis (COA) detailing HPLC purity, mass spectrometry (MS) confirmation, and endotoxin levels are available upon request. We adhere to quality management principles suitable for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥70%
Solubility	Soluble in water, DMSO, or ethanol
Water Content (K.F.)	≤5.0%
Endotoxin Level	<10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.