Description

D-[1-13C,2-2H]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C1 position and deuterium at the C2 position. This precise labeling makes it an indispensable tracer for advanced metabolic research, enabling scientists to track glucose utilization and metabolic flux with high specificity and minimal background interference. It is a critical reagent for researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors, particularly for in vitro and in vivo studies of carbohydrate metabolism, glycolysis, and the pentose phosphate pathway.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotope tracer to quantify intracellular metabolic pathway rates and network regulation.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in studies to understand the metabolic fate of new drug candidates and their interaction with glucose pathways.
• NMR & Mass Spectrometry: Serves as an internal standard or labeled substrate for quantitative analysis using Nuclear Magnetic Resonance (NMR) spectroscopy and LC-MS/MS.
• Biochemical Research: Essential for enzymatic studies, investigating mechanisms of glucose transporters (GLUTs), and exploring metabolic disorders like diabetes and cancer.
• Diagnostic Agent Development: Used in the research and development of novel diagnostic probes and imaging agents for metabolic diseases.

Basic Information

Product Name	D-[1-13C,2-2H]Glucose
CAS No.	201417-06-3
Molecular Formula	C6H112H13CO6
Molecular Weight	183.15 g/mol
Synonyms	1-13C,2-2H-Glucose; D-Glucose-1-13C,2-d; [1-13C,2-2H]D-Glucose; Deuterated and 13C-labeled D-Glucose; Isotopic D-Glucose; Stable Isotope-Labeled Glucose; Glucose (1-13C, 2-2H); D-Glucose-1-13C,2-d1
EINECS	Contact for details

Quality Control

Every batch of D-[1-13C,2-2H]Glucose is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including isotopic enrichment analysis by NMR and MS, chemical purity assessment by HPLC, and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results for isotopic purity, chemical purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Purity (2H)	≥ 98 atom % 2H
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.5° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.