Description

Heptakis(2,3-Di-O-methyl-6-O-sulfo)-β-cyclodextrin is a chemically modified, anionic cyclodextrin derivative designed for advanced molecular recognition and separation science. This compound matters for its unique ability to form selective inclusion complexes with a wide range of guest molecules, driven by its sulfonated and methylated cavity. It is primarily needed by researchers and manufacturers in the pharmaceutical, analytical chemistry, and biotechnology sectors for chiral separations, solubility enhancement, and as a sophisticated component in capillary electrophoresis and chromatographic systems.

Application

• Chiral Resolution Agent: A critical selector in capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) for the separation of enantiomeric drug compounds and intermediates.
• Pharmaceutical Solubility & Stability Enhancer: Used to improve the aqueous solubility, bioavailability, and chemical stability of poorly soluble active pharmaceutical ingredients (APIs) through complexation.
• Analytical Reference Standard: Serves as a high-purity standard for method development and validation in analytical laboratories.
• Biochemical Research: Employed in studies of host-guest interactions, enzyme mimetics, and molecular sensing due to its tailored cavity properties.
• Formulation Excipient: Potential use in advanced drug delivery systems as a functional excipient to control release profiles.
• Chemical Synthesis Intermediate: Acts as a building block for further functionalization to create novel cyclodextrin-based materials and catalysts.

Basic Information

Item	Details
Product Name	Heptakis(2,3-Di-O-methyl-6-O-sulfo)-β-cyclodextrin
CAS No.	201346-23-8
Molecular Formula	C56H91O49S77- • (Counterion)7+
Molecular Weight	Contact for details
Synonyms	Sulfated Heptakis(2,3-di-O-methyl)-β-cyclodextrin; Heptakis(2,3-di-O-methyl-6-sulfo)-β-CD; SBE-β-CD (Heptakis, 2,3-di-O-methyl); β-Cyclodextrin, heptakis(2,3-di-O-methyl-6-sulfo); 2,3-Di-O-methyl-6-O-sulfo-β-cyclodextrin (heptakis); Anionic methylated β-cyclodextrin; CAS 201346-23-8
EINECS	Contact for details

Quality Control

Our Heptakis(2,3-Di-O-methyl-6-O-sulfo)-β-cyclodextrin is produced under a rigorous quality management system. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for research and analytical applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay (HPLC), degree of substitution, residual solvents, and specific optical rotation. We support compliance with relevant ICH guidelines for analytical procedures.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and prevent clumping.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Substitution (Sulfate)	~7.0 (Theoretical)
Water Content (KF)	≤ 8.0 %
Specific Optical Rotation	Contact for details
Residual Solvents (GC)	Meets ICH limits
pH (in solution)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.