Description

Epothilone E is a potent microtubule-stabilizing agent belonging to the epothilone class of natural products. This compound serves as a crucial intermediate and reference standard in pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) for drug discovery, mechanism-of-action studies, and analytical method development.

Application

• Anticancer Drug Discovery: As a lead compound and reference standard for developing novel chemotherapeutic agents targeting microtubule dynamics.
• Biochemical Research: Used in in vitro studies to investigate tubulin polymerization, cell cycle arrest, and apoptosis mechanisms.
• Pharmacology & Toxicology: Employed as a benchmark in preclinical studies to evaluate the efficacy and safety profiles of new epothilone analogs.
• Analytical Reference Standard: Serves as a high-purity calibrant for quality control and analytical method validation using HPLC, LC-MS, and NMR.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and medicinal chemistry.

Basic Information

Product Name	Epothilone E
CAS No.	201049-37-8
Molecular Formula	C27H41NO6S
Molecular Weight	507.68 g/mol
Synonyms	Epothilone E; 4,8-Dimethyl-12-(2-methyl-4-thiazolyl)-10-oxa-2-azabicyclo[10.4.0]hexadeca-1(12),13,15-trien-9-one, (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-; (-)-Epothilone E; Epothilone B 26-Triflate; 26-Trifluoromethanesulfonyloxyepothilone B
EINECS	Contact for details

Quality Control

Our Epothilone E is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.