Description

Chloro[(2-Chlorophenyl)Methyl]Magnesium is a highly reactive organomagnesium reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to act as a powerful nucleophile, introducing the (2-chlorophenyl)methyl group into target molecules with high precision. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and advanced agrochemical industries for constructing key molecular scaffolds and intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of compounds with biphenyl or substituted phenyl motifs.
• Agrochemical Manufacturing: Used in the creation of advanced herbicides, fungicides, and insecticides that require specific chlorinated aromatic structures.
• Fine Chemical Production: Employed in the synthesis of specialty chemicals, dyes, and performance materials where precise aromatic functionalization is required.
• Cross-Coupling Reactions: Serves as a crucial reagent in Kumada and other transition-metal-catalyzed cross-coupling reactions to form biaryl compounds.
• Nucleophilic Addition to Carbonyls: Used for the addition to aldehydes, ketones, and esters to produce secondary and tertiary alcohols with aromatic chlorophenyl groups.
• Material Science Research: Applied in the development of novel organic ligands, monomers for polymers, and liquid crystalline materials.

Basic Information

Product Name	Chloro[(2-Chlorophenyl)Methyl]Magnesium
CAS No.	29874-00-8
Molecular Formula	C7H6Cl2Mg
Molecular Weight	185.33 g/mol
Synonyms	(2-Chlorobenzyl)magnesium chloride; 2-Chlorobenzylmagnesium chloride; (2-Chlorophenyl)methylmagnesium chloride; Magnesium, chloro[(2-chlorophenyl)methyl]-; Grignard reagent (2-chlorobenzyl)MgCl; α-Chloro-o-xylene magnesium complex; (o-Chlorobenzyl)magnesium chloride
EINECS	Contact for details

Quality Control

Every batch of our Chloro[(2-Chlorophenyl)Methyl]Magnesium is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. We employ rigorous analytical protocols, including titration and GC analysis, to verify concentration and assess impurity profiles. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee compliance with your research and process specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated area. Due to its pyrophoric and moisture-sensitive nature, the reagent must be handled exclusively under inert conditions. Keep away from heat, sparks, open flames, and incompatible materials such as water, alcohols, and strong acids.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (by Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.