Description

Teniposide is a semi-synthetic podophyllotoxin derivative and a potent topoisomerase II inhibitor, widely recognized for its critical role in oncology. This compound is valued for its efficacy in disrupting DNA replication in rapidly dividing cells, making it a cornerstone in specific chemotherapeutic regimens. It is primarily required by pharmaceutical manufacturers, research institutions, and compounding facilities engaged in the development and production of injectable anticancer medications.

Application

• Oncological Pharmaceutical Manufacturing: Key active pharmaceutical ingredient (API) in the formulation of injectable chemotherapeutic drugs.
• Acute Lymphoblastic Leukemia (ALL) Treatment: A critical component in combination therapy protocols for pediatric and adult patients with refractory ALL.
• Neuroblastoma and Brain Tumor Therapy: Used in treatment regimens for other solid tumors, including neuroblastoma and certain brain cancers.
• Clinical Research & Drug Development: Serves as a reference standard and investigational compound in preclinical and clinical cancer research studies.
• Biochemical Research: Utilized in molecular biology and pharmacology labs to study topoisomerase II inhibition mechanisms and apoptosis.

Basic Information

Product Name	Teniposide
CAS No.	29767-20-2
Molecular Formula	C32H32O13S
Molecular Weight	656.66 g/mol
Synonyms	VM-26; Vumon; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-2-thenylidene-β-D-glucopyranoside]; NSC 122819; EPT; Tenipod; Teniposid; Podophyllotoxin, 4'-demethylepi-, 9-[4,6-O-(2-thienylmethylene)-β-D-glucopyranoside]
EINECS	249-831-8

Quality Control

Our Teniposide is manufactured under strict quality management systems to meet the stringent requirements of pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmacopeial standards (e.g., USP, EP) and internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.