Description

Teniposide (VM-26) is a semi-synthetic podophyllotoxin derivative and a potent topoisomerase II inhibitor. This compound is a critical active pharmaceutical ingredient (API) valued for its antineoplastic properties in targeted cancer therapy. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of chemotherapeutic formulations.

Application

• Oncological Pharmaceutical Manufacturing: As a key active ingredient in injectable chemotherapy drugs for treating specific leukemias and lymphomas.
• Clinical Research & Development: For preclinical and clinical studies investigating novel cancer treatment protocols and combination therapies.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for drug testing and verification.
• Biochemical Research: Used as a tool compound in molecular biology to study topoisomerase II function, DNA replication, and apoptosis mechanisms.

Basic Information

Product Name	Teniposide (VM-26)
CAS No.	29676-20-2
Molecular Formula	C32H32O13S
Molecular Weight	656.66 g/mol
Synonyms	VM-26; Teniposide; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-2-thenylidene-β-D-glucopyranoside]; NSC 122819; EPT; Vumon; VM 26; Teniposidum
EINECS	249-774-1

Quality Control

Our Teniposide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.