Description

p-Tolyl Triflate (CAS NO 29540-83-8) is a versatile and highly reactive organotriflate reagent, primarily valued as an effective electrophile in cross-coupling reactions. Its core value proposition lies in its ability to serve as a superior leaving group, facilitating the efficient synthesis of complex aryl and heteroaryl compounds. This makes it an indispensable building block for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where the construction of specific carbon-carbon and carbon-heteroatom bonds is critical.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura, Stille, and Negishi cross-coupling reactions for constructing biaryl motifs found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the preparation of novel herbicides, fungicides, and insecticides that require specific substituted aromatic structures.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized phosphine ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Facilitates the creation of conjugated polymers and organic electronic materials through polymerization or functionalization reactions.
• Chemical Biology Probes: Acts as a derivatization agent for labeling biomolecules or synthesizing probe molecules for biochemical studies.
• Fine Chemical Manufacturing: Enables the scalable production of specialty aromatic compounds used in flavors, fragrances, and dyes.

Basic Information

Product Name	p-Tolyl Triflate
CAS No.	29540-83-8
Molecular Formula	C8H7F3O3S
Molecular Weight	240.20 g/mol
Synonyms	4-Methylphenyl trifluoromethanesulfonate; 4-Methylphenyl triflate; p-Tolyl trifluoromethanesulfonate; Trifluoromethanesulfonic acid 4-methylphenyl ester; 4-Tolyl triflate; 1-Methyl-4-(trifluoromethanesulfonyloxy)benzene; p-Cresyl triflate; (4-Methylphenyl) triflate
EINECS	Contact for details

Quality Control

Our p-Tolyl Triflate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.