Description

2-Methyl-Demethyl γ-Amanitin is a chemically modified derivative of the potent amatoxin, γ-amanitin. This compound is of significant interest in biochemical and pharmacological research, particularly as a highly selective inhibitor of RNA polymerase II. It is primarily utilized by research institutions and pharmaceutical development laboratories for studying transcription mechanisms, developing toxin-based conjugates, and exploring targeted therapeutic applications.

Application

• Biochemical Research: Used as a specific and potent inhibitor of eukaryotic RNA polymerase II in mechanistic studies of transcription.
• Pharmacology & Toxicology: Serves as a reference standard and tool compound for investigating the effects of amatoxins and developing potential antidotes.
• Drug Discovery: Employed in the development of antibody-drug conjugates (ADCs) and other targeted therapies due to its extreme cytotoxicity.
• Molecular Biology: Applied in studies of cell cycle arrest, apoptosis, and protein synthesis inhibition.
• Diagnostic Development: Potential use in the creation of assays and kits for the detection of amatoxin poisoning.

Basic Information

Product Name	2-Methyl-Demethyl γ-Amanitin
CAS No.	29030-16-8
Molecular Formula	C38H53N9O13S
Molecular Weight	875.95 g/mol
Synonyms	2-Methyl-γ-amanitin; 2-Methyl-demethyl-γ-amanitin; 2-Me-Demethyl-γ-amanitin; γ-Amanitin, 2-methyl-demethyl-; NSC 529070; 2-Methyl-O-demethyl-γ-amanitin; 2-Methyl-7'-demethyl-γ-amanitin
EINECS	Contact for details

Quality Control

Our 2-Methyl-Demethyl γ-Amanitin is produced and handled under stringent quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.