Description

m-Tolylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its primary value lies in its ability to act as a powerful nucleophile, introducing the m-tolyl (meta-methylphenyl) group into target molecules with high efficiency. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for creating complex aromatic intermediates, active pharmaceutical ingredients (APIs), and specialty chemicals.

Application

• Pharmaceutical Intermediates: A critical reagent for synthesizing complex drug molecules and active pharmaceutical ingredients (APIs) containing meta-substituted toluene structures.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides where the m-tolyl moiety imparts specific biological activity.
• Material Science: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials as a functional monomer or precursor.
• Fine Chemical Production: Serves as a foundational building block for dyes, pigments, fragrances, and other specialty aromatic compounds.
• Cross-Coupling Reactions: Acts as a coupling partner in transition-metal catalyzed reactions, such as Kumada couplings, to form biaryl structures.
• Nucleophilic Addition: Reacts with carbonyl groups (aldehydes, ketones, esters) to produce secondary and tertiary alcohols, a fundamental transformation in synthetic chemistry.

Basic Information

Item	Detail
Product Name	m-Tolylmagnesium Bromide
CAS No.	28987-79-3
Molecular Formula	C7H7BrMg
Molecular Weight	195.34 g/mol
Synonyms	3-Methylphenylmagnesium Bromide; (3-Methylphenyl)magnesium Bromide; m-Tolylmagnesium Bromide solution; Magnesium, bromo(3-methylphenyl)-; meta-Tolylmagnesium Bromide; 3-Tolylmagnesium Bromide; Grignard Reagent m-TolylMgBr; Bromo(3-methylphenyl)magnesium
EINECS	Contact for details

Quality Control

Our m-Tolylmagnesium Bromide is manufactured under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration (typically supplied as a solution in THF or diethyl ether), assay, and impurity profiles. Our quality systems are designed to meet the exacting standards required for GMP and cGMP manufacturing environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive (hygroscopic) nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For solutions, store at recommended temperatures (typically 2-8°C or as specified) and keep away from heat, sparks, and open flames. Handle and store separately from strong acids, oxidizing agents, and water.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Identification (IR)	Conforms
Concentration (in THF/Et2O)	0.5 M - 2.0 M (Customizable)
Assay (Titration)	≥ 95%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.