Description

Nigericin Sodium Salt CAS NO 28643-80-3 is a polyether antibiotic and a potent ionophore, specifically exchanging K+ for H+ across biological membranes. This compound is a critical research tool for studying mitochondrial function, cellular bioenergetics, and ion transport mechanisms. It is primarily utilized by researchers and scientists in the fields of biochemistry, cell biology, and pharmacology for applications such as uncoupling oxidative phosphorylation and modulating intracellular pH.

Application

• Biochemical Research: Used as a potassium-proton ionophore to study mitochondrial respiration, membrane potential, and ATP synthesis.
• Cell Biology Studies: Employed to uncouple oxidative phosphorylation, investigate cellular bioenergetics, and induce apoptosis in experimental models.
• Ion Transport Mechanism Analysis: A key tool for probing the function of potassium channels and other ion transport systems in vitro.
• Pharmacology & Toxicology: Used in research to understand the effects of ionophores on cell viability and metabolic pathways.
• Antibiotic Research: Serves as a reference compound in studies of polyether antibiotics and their mechanisms of action.
• Diagnostic Reagent Development: May be incorporated into assay kits for measuring mitochondrial function or membrane permeability.

Basic Information

Product Name	Nigericin Sodium Salt
CAS No.	28643-80-3
Molecular Formula	C40H67O11Na
Molecular Weight	746.94 g/mol
Synonyms	Nigericin Sodium; Antibiotic K178; Azalomycin M; Helixin C; Polyetherin A; Antibiotic X-464; NSC 157013; (2R)-2-[(2R,5R,7S,8S,9R)-5-[(2S,3S,5R)-5-[(2S,3S,5R)-3,5-Dimethyl-6-oxo-2-tetrahydropyranyl]-3-methyl-2-tetrahydrofuranyl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-2-methylbutyric Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Nigericin Sodium Salt is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Biological Activity	Tested

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.