Description

4-Fluoro-3-Picoline is a high-purity fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom adjacent to the nitrogen in the pyridine ring, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine motifs for enhanced bioactivity, metabolic stability, or material characteristics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of fluorinated liquid crystals, organic semiconductors, and polymers with specific electronic or surface properties.
• Chemical Biology Probes: Useful for creating fluorinated analogs of natural products or biomarkers for metabolic and imaging studies.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under GMP or ISO standards.

Basic Information

Product Name	4-Fluoro-3-Picoline
CAS No.	28489-28-3
Molecular Formula	C6H6FN
Molecular Weight	111.12 g/mol
Synonyms	3-Methyl-4-fluoropyridine; 4-Fluoro-3-methylpyridine; 4-Fluoro-3-picoline; 4-Fluor-3-methylpyridin; 3-Picoline, 4-fluoro-; 4-Fluoro-3-methylpyridine (3-Methyl-4-fluoropyridine)
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Picoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with ISO 9001 standards, and we support customers requiring material for use in regulated environments under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Related Substances (GC/HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.