Description

Nigericin Sodium Salt CAS NO 28380-24-7 is a potent, monovalent cation-selective ionophore derived from *Streptomyces hygroscopicus*. This compound is a critical research tool for studying ion transport across biological membranes, particularly for potassium-proton exchange. It is essential for researchers in biochemistry and cell biology who require a reliable agent to uncouple oxidative phosphorylation, dissipate mitochondrial membrane potential, and modulate intracellular pH. Its primary utility spans academic research, pharmaceutical development, and biotechnology applications focused on bioenergetics and cellular physiology.

Application

• Mitochondrial Research: Used extensively as an uncoupler of oxidative phosphorylation to study mitochondrial function, membrane potential, and bioenergetics.
• Ion Transport Studies: Serves as a selective K+/H+ antiporter to investigate monovalent cation flux and pH homeostasis across lipid bilayers and cellular membranes.
• Cell Biology & Apoptosis: Employed to induce apoptosis in cell culture models by disrupting mitochondrial membrane potential and triggering the intrinsic pathway.
• Antibiotic Research: Studied for its antimicrobial properties against Gram-positive bacteria and its role as a model ionophore antibiotic.
• Biochemical Assays: Utilized in various in vitro assays to modulate ionic gradients and study the activity of membrane-bound enzymes and transporters.
• pH Modulation Experiments: Applied in experimental protocols to artificially alter intracellular or intra-organellar pH for functional studies.

Basic Information

Product Name	Nigericin Sodium Salt
CAS No.	28380-24-7
Molecular Formula	C40H67O11.Na
Molecular Weight	746.95 g/mol
Synonyms	Nigericin sodium; Antibiotic K 178; Azalomycin M; Helixin C; Polyetherin A; Antibiotic X-464; [1]Benzopyrano[4,3-b][1]benzopyran-5(10bH)-one, 3,4,4a,5,6,10b-hexahydro-9,10-dihydroxy-3,4a,7,7,10a-pentamethyl-, sodium salt; (2R,3S,4R,5R,8S,10S,11S,12S,13R)-13-[(2S,3S,4R,5S)-5-[(2S,3S,4S,5R)-4-[(2R,3R,4S,5S)-3,4-Dihydroxy-3,5,12-trimethyl-9-oxotridecyl]-3,5-dihydroxytetrahydro-2H-pyran-2-yl]-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-2-ethyl-3,4,5,8,10,11,12-heptahydroxy-2,10,12-trimethyl-15-oxo-3,5,9-trioxapentadecan-13-oate sodium salt
EINECS	Contact for details

Quality Control

Our Nigericin Sodium Salt is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Potency (Microbial)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.