Description

4-(Cyanomethyl)Benzene-1-Sulfonyl Chloride is a versatile and highly reactive organic intermediate, primarily used as a key building block in the synthesis of more complex molecules. Its value lies in the dual functionality of the sulfonyl chloride and cyanomethyl groups, enabling a wide range of chemical transformations, particularly in the formation of sulfonamides. This compound is essential for research and development chemists and process engineers working in the pharmaceutical and agrochemical industries, where it is employed to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require a sulfonamide pharmacophore.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing sulfonated dyes and colorants with enhanced properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for studying enzyme function and protein labeling.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom chemical synthesis services targeting specialized molecular scaffolds.

Basic Information

Item	Details
Product Name	4-(Cyanomethyl)Benzene-1-Sulfonyl Chloride
CAS No.	28338-22-9
Molecular Formula	C8H6ClNO2S
Molecular Weight	215.66 g/mol
Synonyms	4-(Cyanomethyl)benzenesulfonyl chloride; p-(Cyanomethyl)benzenesulfonyl chloride; (4-Chlorosulfonylphenyl)acetonitrile; 4-(Chlorosulfonyl)phenylacetonitrile; 2-[4-(Chlorosulfonyl)phenyl]acetonitrile; Benzeneacetonitrile, 4-(chlorosulfonyl)-; α-Cyano-p-toluenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Cyanomethyl)Benzene-1-Sulfonyl Chloride is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity. Our standard analytical control includes identification by FT-IR and NMR, purity determination by HPLC, and specific tests for key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.