Description

Chaetocin is a potent and specific natural product inhibitor of histone methyltransferases, particularly SUV39H1. This compound is a critical research tool for epigenetics and oncology studies, enabling the investigation of chromatin remodeling and gene expression regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutic strategies for cancer and other diseases.

Application

• Epigenetics Research: A key molecular probe for studying histone methylation dynamics and chromatin biology.
• Oncology Studies: Used to investigate the role of histone methyltransferases in cancer cell proliferation, apoptosis, and differentiation.
• Biochemical Assay Development: Serves as a reference standard and inhibitor in high-throughput screening (HTS) and in vitro enzymatic assays.
• Drug Discovery: A lead compound for the development of novel epigenetic-targeted therapies.
• Cell Biology: Used to modulate gene expression patterns in various cell lines to understand cellular pathways.
• Academic Research: Essential for fundamental research in molecular biology, genetics, and disease mechanisms.

Basic Information

Product Name	Chaetocin
CAS No.	28097-03-2
Molecular Formula	C30H28N6O6S6
Molecular Weight	729.02 g/mol
Synonyms	NSC 311153; Antibiotic from Chaetomium minutum; Chaetocin A; Histone Methyltransferase Inhibitor I; SUV39H1 Inhibitor; 3,6,10,13,16,19-Hexathia-1,8(2,5)-dipyridina-4,11,18,25(1,4)-tetrabenzenacyclooctacosaphane-2,5,9,12,17,20-hexaone
EINECS	Contact for details

Quality Control

Our Chaetocin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity (IC50)	Reported (SUV39H1)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.