Description

Trimethoprim n-Oxide 1 is a key chemical intermediate and metabolite of the antibiotic trimethoprim. This compound matters for its critical role in pharmaceutical research, development, and quality control processes. It is primarily needed by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors for analytical reference standards, metabolite studies, and the synthesis of advanced drug substances.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of trimethoprim and its metabolites in drug substance and product analysis.
• Metabolite Research: Serves as a critical standard in pharmacokinetic and metabolic pathway studies to understand the biotransformation of trimethoprim.
• Impurity Profiling: Employed in the development and validation of analytical methods (e.g., HPLC, LC-MS) to monitor and control related substances in active pharmaceutical ingredients (APIs).
• Chemical Synthesis Intermediate: Acts as a building block or precursor in the research-scale synthesis of novel trimethoprim derivatives or related antimicrobial agents.
• Quality Control & Assurance: Essential for in-house quality control laboratories to ensure the purity, safety, and efficacy of trimethoprim-based drug products.
• Regulatory Compliance Testing: Supports testing to meet pharmacopoeial standards (e.g., USP, EP, BP) and regulatory submission requirements for drug approval.

Basic Information

Product Name	Trimethoprim n-Oxide 1
CAS No.	27653-68-5
Molecular Formula	C14H18N4O4
Molecular Weight	306.32 g/mol
Synonyms	2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-Oxide; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine 1-Oxide; Trimethoprim 1-Oxide; Trimethoprim N-Oxide; Trimethoprim N(1)-Oxide; TMP N-Oxide; NSC 329860
EINECS	Contact for details

Quality Control

Our Trimethoprim n-Oxide 1 is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.