Description

8-Iso Prostaglandin E2 is a bioactive isoprostane, a class of prostaglandin-like compounds formed from the free radical-catalyzed peroxidation of arachidonic acid. This compound is of significant value as a biomarker for oxidative stress and a potent tool in pharmacological research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers for studying inflammation, cardiovascular disease, and lipid peroxidation pathways.

Application

• Biomarker Research: Used as a reference standard in analytical methods (LC-MS/MS, ELISA) to quantify oxidative stress levels in biological samples.
• Pharmacological Studies: Employed to investigate the biological activity and receptor interactions of isoprostanes in cell-based and in vivo models.
• Diagnostic Development: Serves as a critical calibrant and control in the development and validation of commercial diagnostic assays for oxidative stress.
• Drug Discovery: Used in screening programs to identify novel compounds that modulate isoprostane pathways or mitigate oxidative damage.
• Academic Research: A key reagent for studies in biochemistry, physiology, and pathology related to free radical biology and eicosanoid signaling.
• Reference Material: Provides a high-purity standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	8-Iso Prostaglandin E2
CAS No.	27415-25-4
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	8-iso-PGE2; 8-epi-Prostaglandin E2; 15(S)-8-iso-Prostaglandin E2; 8-iso Prostaglandin E2; Isoprostane E2; 8-Epi-PGE2; 15S-8-iso-PGE2; (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid
EINECS	Contact for details

Quality Control

Our 8-Iso Prostaglandin E2 is produced and handled under strict quality management protocols to ensure high purity and batch-to-batch consistency, critical for research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards suitable for research and in-vitro diagnostic use. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.