Description

Antimycin A4 is a specific, naturally occurring antibiotic compound belonging to the antimycin family, a group of potent inhibitors of mitochondrial electron transport. This high-purity chemical is valued in research and development for its precise biological activity, serving as a critical tool for studying cellular respiration, apoptosis, and bioenergetics. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic pathway analysis and drug discovery programs.

Application

• Biochemical Research: As a specific inhibitor of the mitochondrial electron transport chain (complex III), used to study cellular respiration, oxidative phosphorylation, and ATP production mechanisms.
• Apoptosis Studies: Employed to induce and investigate programmed cell death pathways in various cell lines, aiding cancer and neurodegenerative disease research.
• Metabolic Pathway Analysis: A key reagent for probing metabolic flux and energy metabolism in mitochondria, useful for understanding metabolic disorders.
• Antifungal & Pesticide Research: Serves as a reference standard and active component in studies exploring its natural pesticidal and antifungal properties.
• Pharmaceutical Development: Used as a lead compound or pharmacological tool in early-stage drug discovery targeting mitochondrial dysfunction.
• Academic & Industrial R&D: Supplied to laboratories for use in standard assays and experimental protocols requiring a reliable electron transport chain inhibitor.

Basic Information

Product Name	Antimycin A4
CAS No.	27220-59-3
Molecular Formula	C28H40N2O9
Molecular Weight	548.63 g/mol
Synonyms	Antimycin A IV; Antimycin A4; Antimycin A-4; 3-Formamido-2-hydroxybenzoyl-L-threonyl-D-alloisoleucyl-L-valine lactone (3'-methylbutanoate); Antibiotic A4; NSC 133089; Antimycin A component A4
EINECS	Contact for details

Quality Control

Our Antimycin A4 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research-grade chemicals, and custom purity grades or specific analytical data can be provided upon request to meet your precise experimental requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. For long-term storage, consider keeping the product in a freezer at -20°C under an inert atmosphere to maintain stability. The container should be kept in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.