Description

8-Iso Prostaglandin F1β is a chemically stable isoprostane, a class of prostaglandin-like compounds formed in vivo by non-enzymatic free-radical peroxidation of arachidonic acid. This compound serves as a crucial biomarker for oxidative stress and lipid peroxidation in biological systems. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on cardiovascular disease, neurodegenerative disorders, and aging research, where accurate quantification of oxidative damage is essential.

Application

• Biomarker Research: Used as a primary analytical standard for the quantification of oxidative stress in clinical and preclinical studies.
• Pharmaceutical Development: Employed in drug discovery programs targeting diseases linked to oxidative damage, such as atherosclerosis, Alzheimer's, and diabetes.
• Diagnostic Assays: Serves as a critical reference compound in the development and calibration of ELISA kits and LC-MS/MS methods for isoprostane detection.
• Nutritional & Cosmetic Science: Applied in studies evaluating the efficacy of antioxidants and nutraceuticals in reducing lipid peroxidation.
• Toxicology Studies: Used to assess oxidative injury caused by environmental toxins, pharmaceuticals, or industrial chemicals.
• Academic Research: Fundamental tool in biochemistry and cell biology laboratories investigating the mechanisms of free radical biology and inflammation.

Basic Information

Product Name	8-Iso Prostaglandin F1β
CAS No.	26771-95-9
Molecular Formula	C₂₀H₃₄O₅
Molecular Weight	354.48 g/mol
Synonyms	8-iso-PGF1β; 8-iso-Prostaglandin F1β; 15-F2t-IsoP; 8-Epi-prostaglandin F1β; 8-epi-PGF1β; 15-F2t-Isoprostane; (5Z,13E,15S,17Z)-9,11,15-Trihydroxyprosta-5,13,17-trien-1-oic acid; F2-Isoprostane
EINECS	Contact for details

Quality Control

Our 8-Iso Prostaglandin F1β is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be allowed to reach room temperature before opening to minimize moisture ingress and should be flushed with an inert gas after use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, methanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.