Description

Phallacidin CAS NO 26645-35-2 is a bicyclic heptapeptide mycotoxin and a potent inhibitor of actin polymerization. This compound is of significant value in biochemical and pharmacological research for its ability to bind to F-actin and stabilize actin filaments, thereby disrupting the dynamic equilibrium of the cytoskeleton. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cell biology studies, cytoskeletal research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a critical tool compound to study actin filament dynamics, cell motility, and cytoskeletal architecture.
• Pharmacological Studies: Employed in the investigation of cellular processes such as cytokinesis, intracellular transport, and muscle contraction mechanisms.
• Toxicology Research: Serves as a reference standard and model toxin for studying the effects of phallotoxins and amatoxins.
• Drug Discovery: Utilized in high-throughput screening assays to identify novel compounds that modulate actin polymerization for potential therapeutic applications in cancer and other diseases.
• Academic Research: A key reagent in university laboratories for teaching and advanced research in molecular and cellular biology.

Basic Information

Item	Detail
Product Name	Phallacidin
CAS No.	26645-35-2
Molecular Formula	C39H54N8O12S
Molecular Weight	858.96 g/mol
Synonyms	Phallacidin; NSC 332771; Phallacidine; Amanita phalloides toxin derivative; F-actin stabilizing toxin; Cyclo(L-alanyl-D-tryptophyl-L-cysteinyl-trans-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophylglycyl), cyclic (4→7)-disulfide; Phalloidin derivative
EINECS	Contact for details

Quality Control

Our Phallacidin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analysis including HPLC for purity determination and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.