Description

1-Trifluoromethyl-Naphthalene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role in introducing the trifluoromethyl group, a key moiety known to dramatically alter the physicochemical properties of molecules, enhancing metabolic stability, lipophilicity, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 group can improve weather resistance and biological activity.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of electronic materials for displays and lighting, contributing to improved charge transport and stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Negishi) and as a precursor for more complex fluorinated naphthalene derivatives.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing specialized fluorinated dyes with unique color fastness and spectral properties.
• Academic & Industrial Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorination in various chemical contexts.

Basic Information

Product Name	1-Trifluoromethyl-Naphthalene
CAS No.	26458-04-8
Molecular Formula	C11H7F3
Molecular Weight	196.17 g/mol
Synonyms	α-Trifluoromethylnaphthalene; (Trifluoromethyl)naphthalene; Naphthalene, 1-(trifluoromethyl)-; 1-(Trifluoromethyl)naphthalene; 1-Naphthyltrifluoromethane; 1-CF3-Naphthalene; NSC 404087; 1-Trifluoromethylnaphthalene
EINECS	Contact for details

Quality Control

Our 1-Trifluoromethyl-Naphthalene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Purity (GC/HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.