Description

Pyridin-D4-4-Amine CAS NO 26257-21-6 is a deuterium-labeled derivative of 4-aminopyridine, serving as a critical internal standard and tracer in advanced analytical chemistry. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and NMR studies, where isotopic purity is paramount. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in pharmacokinetics, metabolic pathway analysis, and the synthesis of labeled compounds.

Application

• Internal Standard for LC-MS/MS: Used for the precise quantification of 4-aminopyridine and related compounds in complex biological matrices like plasma and tissue homogenates.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track and elucidate metabolic pathways using deuterium as a stable isotopic label.
• NMR Spectroscopy: Serves as a valuable probe in nuclear magnetic resonance spectroscopy for mechanistic studies and structural analysis due to its distinct deuterium signature.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for quality control and method validation in pharmaceutical analysis and regulatory submissions.
• Synthesis of Labeled Compounds: Used as a key building block in the synthesis of more complex deuterium-labeled molecules for research and diagnostic applications.
• Environmental and Food Safety Analysis: Applied in advanced analytical methods to detect and quantify pyridine-based compounds in environmental samples and food products.

Basic Information

Product Name	Pyridin-D4-4-Amine
CAS No.	26257-21-6
Molecular Formula	C5D4N2
Molecular Weight	100.13 g/mol
Synonyms	4-Aminopyridine-d4; 4-AP-d4; 4-Pyridinamine-d4; Deuterated 4-Aminopyridine; 4-Amino-D4-pyridine; γ-Pyridylamine-d4; 4-Pyridylamine-d4; Ampyra-d4 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Pyridin-D4-4-Amine is manufactured and tested under strict quality management systems to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research and analytical standards. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.