Description

4-(Difluoromethyl)-1-Fluorobenzene is a high-purity fluorinated aromatic building block of significant commercial interest. This compound is valued for its unique reactivity profile, enabling the introduction of difluoromethyl and fluorine substituents into complex molecular architectures. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental profile.
• Material Science Precursor: Employed in the research and development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic fluorine content.
• Organic Synthesis Building Block: Facilitates various cross-coupling and functionalization reactions in medicinal and process chemistry for constructing complex molecules.
• Fluorine Chemistry Research: Serves as a standard or starting material in academic and industrial R&D focused on novel fluorination methodologies and reaction mechanisms.

Basic Information

Product Name	4-(Difluoromethyl)-1-Fluorobenzene
CAS No.	26132-51-4
Molecular Formula	C7H5F3
Molecular Weight	146.11 g/mol
Synonyms	1-Fluoro-4-(difluoromethyl)benzene; α,α-Difluoro-p-fluorotoluene; p-(Difluoromethyl)fluorobenzene; 4-Fluorobenzylidene difluoride; (4-Fluorophenyl)difluoromethane; Benzene, 1-(difluoromethyl)-4-fluoro-; p-Fluoro-α,α-difluorotoluene
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-1-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets your precise research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatility.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.