Description

Benzenesulfonylfluoride, 3-Chloro-4-Methyl- CAS NO 25300-22-5 is a specialized organosulfur compound featuring a reactive sulfonyl fluoride group. This chemical is a critical building block and reagent in advanced organic synthesis, particularly valued for its role in creating sulfonamide linkages. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides that incorporate sulfonyl groups for enhanced efficacy.
• Chemical Biology & Proteomics: Serves as a reactive probe in activity-based protein profiling (ABPP) to study enzyme function and discover new drug targets.
• Material Science Research: Employed in the creation of novel polymers and advanced materials with specific surface functionalities.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed and other metal-mediated cross-coupling reactions.
• Sulfonylation Reagent: Used to introduce the benzenesulfonyl moiety into various organic molecules under controlled conditions.

Basic Information

Product Name	Benzenesulfonylfluoride, 3-Chloro-4-Methyl-
CAS No.	25300-22-5
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	3-Chloro-4-methylbenzenesulfonyl fluoride; 4-Methyl-3-chlorobenzenesulfonyl fluoride; 1-Chloro-2-methyl-5-fluorosulfonylbenzene; 3-Chloro-p-toluenesulfonyl fluoride; 3-Chloro-4-methylbenzene-1-sulfonyl fluoride; 3-Chloro-4-methylphenylsulfonyl fluoride; Benzenesulfonyl fluoride, 3-chloro-4-methyl-
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Methylbenzenesulfonyl fluoride is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.