Description

12-Deoxyphorbol 13-Isobutyrate 20-Acetate is a high-purity, semi-synthetic diterpene ester derived from a phorbol backbone. This compound is of significant interest in biochemical and pharmacological research due to its role as a key intermediate and reference standard in the study of protein kinase C (PKC) modulation and related signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutic agents and studying tumor promotion mechanisms.

Application

• Biochemical Research: Serves as a critical reference standard and intermediate in the study of protein kinase C (PKC) activators and inhibitors.
• Pharmaceutical R&D: Used as a building block or a pharmacological probe in the discovery and development of novel anti-cancer and anti-inflammatory agents.
• Toxicology Studies: Employed as a model compound for investigating the mechanisms of tumor promotion and skin irritation associated with certain diterpene esters.
• Academic Research: Utilized in universities and research institutes for fundamental studies on cell signaling, apoptosis, and differentiation.
• Fine Chemical Synthesis: Acts as a sophisticated starting material or intermediate for the synthesis of more complex, biologically active diterpenoid analogs.
• Standards and Metrology: Supplied as a certified reference material (CRM) for analytical method development and validation in regulatory and quality control environments.

Basic Information

Product Name	12-Deoxyphorbol 13-Isobutyrate 20-Acetate
CAS No.	25090-71-5
Molecular Formula	C28H38O7
Molecular Weight	486.60 g/mol
Synonyms	12-Deoxyphorbol 13-isobutyrate 20-acetate; 12-Deoxyphorbol 13-isobutyryl-20-acetate; 20-Acetoxy-12-deoxyphorbol 13-isobutyrate; NSC 153858; 12-Deoxyphorbol-13-isobutyrate-20-acetate; Phorbol 13-isobutyrate 20-acetate, 12-deoxy-; 12-DPA
EINECS	Contact for details

Quality Control

Our 12-Deoxyphorbol 13-Isobutyrate 20-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.