Description

(2-Iodophenyl)Methanesulphonyl Chloride is a specialized organosulfur building block featuring both an aryl iodide and a sulfonyl chloride functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of sulfonamide-based drugs.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides that leverage sulfonylurea or sulfonamide motifs.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Chemical Biology & Proteomics: Utilized as a reactive handle for bioconjugation and the development of chemical probes targeting specific proteins or enzymes.
• Catalyst & Ligand Synthesis: Employed in the preparation of specialized ligands for transition metal catalysis, particularly where the iodine allows for further functionalization via cross-coupling reactions.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	(2-Iodophenyl)Methanesulphonyl Chloride
CAS No.	25068-94-4
Molecular Formula	C7H6ClIO2S
Molecular Weight	316.54 g/mol
Synonyms	2-Iodobenzenemethanesulfonyl Chloride; (2-Iodophenyl)methanesulfonyl Chloride; α-Toluenesulfonyl Chloride, 2-iodo-; 2-Iodobenzylsulfonyl Chloride; 1-Iodo-2-(chlorosulfonylmethyl)benzene; o-Iodobenzylsulfonyl Chloride; Benzenemethanesulfonyl chloride, 2-iodo-
EINECS	Contact for details

Quality Control

Our (2-Iodophenyl)Methanesulphonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.