Description

3-Methyl-3H-Diazirine-3-Ethanol 4-Methylbenzenesulfonate is a specialized diazirine-based photoaffinity labeling reagent. This compound is critical for advanced biochemical research, enabling the covalent cross-linking of biomolecules upon activation with UV light. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and chemical biology for mapping molecular interactions and drug target identification.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging proteins, nucleic acids, and other biomolecules to study binding sites and interaction networks.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and target identification for novel drug candidates.
• Bioconjugation & Probe Synthesis: Serves as a versatile building block for synthesizing photoactivatable probes and cross-linkers.
• Materials Science: Applied in surface functionalization and the development of light-responsive polymeric materials.
• Chemical Biology Tool Development: Integral for creating tools to investigate enzyme mechanisms and metabolic pathways in live cells.

Basic Information

Product Name	3-Methyl-3H-Diazirine-3-Ethanol 4-Methylbenzenesulfonate
CAS No.	25055-84-9
Molecular Formula	C12H16N2O3S
Molecular Weight	268.33 g/mol
Synonyms	3-(Hydroxymethyl)-3-methyldiaziridine Tosylate; 3-Methyl-3-(2-hydroxyethyl)diazirine p-Toluenesulfonate; 3-Methyl-3H-diazirin-3-ylethanol Tosylate; Photoactivatable Tosylate Ester; Diazirine Tosylate Reagent; PAL Tosylate Reagent; 3-Methyldiaziridine-3-ethanol p-Toluenesulfonate
EINECS	Contact for details

Quality Control

Our 3-Methyl-3H-Diazirine-3-Ethanol 4-Methylbenzenesulfonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.