Description

(3-Fluoro-Phenyl)-Methanesulfonyl Chloride is a versatile and high-purity sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its reactivity as an electrophile, enabling the efficient introduction of the (3-fluorophenyl)methanesulfonyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated phenylsulfonyl group enhances biological activity and stability.
• Material Science: Building block for synthesizing specialized polymers, liquid crystals, and organic electronic materials requiring specific sulfonyl functionalities.
• Chemical Biology & Proteomics: Employed as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis and scale-up projects.
• Sulfonation Reagent: Acts as a sulfonating agent to introduce sulfonyl groups into aromatic and heteroaromatic systems under mild conditions.

Basic Information

Item	Details
Product Name	(3-Fluoro-Phenyl)-Methanesulfonyl Chloride
CAS No.	24974-72-9
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	3-Fluorophenylmethanesulfonyl chloride; (3-Fluorophenyl)methanesulfonyl chloride; 1-Fluoro-3-(chlorosulfonylmethyl)benzene; m-Fluorobenzylsulfonyl chloride; α-Chlorosulfonyl-3-fluorotoluene; 3-Fluoro-α-toluenesulfonyl chloride; (3-Fluorobenzyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (3-Fluoro-Phenyl)-Methanesulfonyl Chloride is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, with specifications tailored to meet the rigorous demands of research and commercial synthesis. Comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.