Description

(2-Fluoro-Phenyl)-Methanesulfonyl Chloride CAS NO 24974-71-8 is a high-purity organosulfur reagent featuring a reactive sulfonyl chloride group and a fluorine-substituted aromatic ring. This compound matters as a critical building block for synthesizing sulfonamide derivatives, which are pivotal in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for creating novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the development of new herbicides and fungicides where the sulfonamide moiety imparts biological activity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with specific surface functionalities.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	(2-Fluoro-Phenyl)-Methanesulfonyl Chloride
CAS No.	24974-71-8
Molecular Formula	C7H6ClFO2S
Molecular Weight	208.64 g/mol
Synonyms	2-Fluorobenzenemethanesulfonyl chloride; (2-Fluorophenyl)methanesulfonyl chloride; α-Toluenesulfonyl chloride, 2-fluoro-; 2-Fluorobenzylsulfonyl chloride; 1-(Chlorosulfonyl)methyl-2-fluorobenzene; o-Fluorobenzylsulfonyl chloride; (o-Fluorophenyl)methanesulfonyl chloride; 24974-71-8
EINECS	Contact for details

Quality Control

Our (2-Fluoro-Phenyl)-Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.